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First Published Study in Venous Leg Ulcers

Evaluation of wound fluid markers to determine healing in adults with Venous Leg Ulcers - A Prospecitive Study.


The study aim was to evaluate whether any of a panel of biomarkers can determine healing status of chronic Venous Leg Ulcers (VLU's). 

From 42 patients,105 evaluable weekly time points were analyzed.  The study found that two specific biomarkers from wound fluid can predict healing status in Chronic Venous Leg Ulcers.  These findings can determine the healing status of a wound and the ability to modify treatment accordingly. 

Biiomarker 1: GMCSF  - 92% accuracy in discriminating healing vs non healing wounds with a demonstrated sensitivity of 96%.

Biomarker 2: MP - 13  - 78% accuracy in discriminating healing vs non healing wounds.

Dr. Michael C. Stacey DS et al: Evaluation of wound fluid biomarkers to determine healing in adults with venous leg ulcers: a prospective study. Published in the Wound Repair & Regeneration 2019

The Research







for personalized management of chronic wounds. Patients with chronic wounds continue to suffer as the clinicians do not have tools to direct optimized healing strategies. I have been conducting research in this area for more than 30 years and I have aspired to have such a tool available in my practice."
Dr. Michael Stacey, MBBS, DS, FRACS, Vascular Surgery
Results currently published in the Journal - Wound Repair and Regeneration. 
Biomarker based diagnostic testing will be a powerful new technology in the wound care space.  

Stunning Foot Facts

  • Every 1.2 seconds someone develops a diabetic foot ulcer
  • Seconds Count: Every 7 seconds someone dies from diabetes. 
  • Every 20 seconds someone is amputated
         DF Blog, Dr. David Armstrong
Dr. Michael Stacey will be commencing a Diabetic Foot Ulcer Study in January 2020.
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